Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens
نویسندگان
چکیده
منابع مشابه
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and ap...
متن کاملGene function prediction from synthetic lethality networks via ranking on demand
MOTIVATION Synthetic lethal interactions represent pairs of genes whose individual mutations are not lethal, while the double mutation of both genes does incur lethality. Several studies have shown a correlation between functional similarity of genes and their distances in networks based on synthetic lethal interactions. However, there is a lack of algorithms for predicting gene function from s...
متن کاملSynthetic lethality--a new direction in cancer-drug development.
In this issue of the Journal, Fong et al. report the results of a phase 1 trial of a new cancer therapy involving 60 patients (ClinicalTrials.gov number, NCT00516373).1 Readers may be surprised by the editors’ decision to publish a small early-stage trial, but this trial not only reports important results — it also points to a new direction in the development of anticancer drugs. Modern cancerd...
متن کاملThe QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens
SUMMARY Neglected tropical diseases (NTDs) caused by helminths constitute some of the most common infections of the world's poorest people. The etiological agents are complex and recalcitrant to standard techniques of molecular biology. Drug screening against helminths has often been phenotypic and typically involves manual description of drug effect and efficacy. A key challenge is to develop ...
متن کاملSSLPred : Predicting Synthetic Sickness Lethality
Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes. SSL interactions are useful to discover the co-expressed gene groups in the regulatory and signaling networks. Also, they are used...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2016
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057116644890